The Man from U.N.C.L.E. is an American spy fiction television series produced by Metro-Goldwyn-Mayer Television and first broadcast on NBC. The series follows secret agents, played by Robert Vaughn and David McCallum, who work for a secret international counterespionage and law-enforcement agency called U.N.C.L.E. The series premiered on September 22, 1964, completing its run on January 15, 1968. The program led the spy-fiction craze on television, and by 1966 there were nearly a dozen imitators. Several episodes were successfully released to theaters as B movies or double features. There was also a spin-off series, The Girl from U.N.C.L.E., novel and comic book series, and merchandising.

With few recurring characters, the series attracted many high-profile guest stars. Props from the series are exhibited at the Ronald Reagan Presidential Library and Museum and at the museums of the Central Intelligence Agency and other US intelligence agencies. The series won the Golden Globe Award for Best TV Show in 1966.

Originally, co-creator Sam Rolfe wanted to leave the meaning of U.N.C.L.E. ambiguous so it could refer to either "Uncle Sam" or the United Nations.^: 14 Concerns by the MGM legal department about using "U.N." for commercial purposes resulted in the producers' clarification that U.N.C.L.E. was an acronym for the United Network Command for Law and Enforcement. Each episode had an "acknowledgement" to the U.N.C.L.E. in the end titles.